Marco Bortolato Selected Publications

Bortolato recent publications and previous publications on aggression, alcohol and cannabis

  1. Moskovitz J, Walss-Bass C, Cruz DA, Thompson PM, Bortolato M. Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity. Int J Neuropsychopharmacol, in press
  2. Frau R, Bini V, Pillolla G, Malherbe P, Pardu A, Thomas AW, Devoto P, Bortolato M. Positive allosteric modulation of GABA-B receptors ameliorates sensorimotor gating in rodent models. CNS Neuroscience and Therapeutics, in press
  3. Godar SC, Bortolato M. Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission. Front in Behav Neurosci, in press
  4. Bortolato M, Bini V, Frau R, Devoto P, Pardu A, Fan Y, Solbrig MV. Juvenile cannabinoid treatment induces frontostriatal gliogenesis in Lewis rats. Eur Neuropsychopharmacol , in press
  5. Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC.  Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. 2013 Dec;75:223-32.
  6. Tambaro S, Tomasi ML, Bortolato M. Long-term CB1 receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids. Neuropharmacology. 2013 Jul;70:268-77.
  7. Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, Bini V, Chen K, Wellman CL, Lin RC, Shih JC. Monoamine oxidase A and A/B knockout mice display autistic-like features. Int J Neuropsychopharmacol. 2013 May;16(4):869-88.
  8. Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC. NMDARs mediate the role of monoamine oxidase A in pathological aggression. J Neurosci. 2012 Jun 20;32(25):8574-82.
  9. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan;37(1):8-15.
  10. Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL. Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology. 2012 Aug;63(2):190-201.
  11. Tambaro S, Bortolato M. Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Pat CNS Drug Discov. 2012 Apr 1;7(1):25-40.
  12. Bortolato M, Shih JC. Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. Int Rev Neurobiol. 2011;100:13-42.
  13. Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I, Farrell MR, Scott AL,  Wellman CL, Shih JC. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology. 2011 Dec;36(13):2674-88.
  14. Godar SC*, Bortolato M*, Frau R, et al. Maladaptive defensive behaviors in monoamine oxidase A-deficient mice. Int J Neuropsychopharmacol. 2011 Oct;14(9):1195-207.
  15. Bortolato M, Bini V, Tambaro S. Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis. Pharmaceuticals, 2010; 3(9): 2799-2820
  16. Bortolato M, Frau R, Bini V, Luesu W, et al. Methamphetamine neurotoxicity increases brain expression and alters behavioral functions of CB1 cannabinoid receptors. J Psychiatr Res. 2010; 44(14): 944-55.
  17. Sciolino NR, Bortolato M, Eisenstein SA, Fu J, et al. Social isolation and chronic handling alter the endocannabinoid signaling system and behavioral reactivity to context in adult rats. Neuroscience 2010; 168(2): 371-86
  18. Bortolato M, Frau R, Piras AP, Luesu W, et al. Methamphetamine induces long-term alterations in reactivity to environmental stimuli: correlation with dopaminergic and serotonergic toxicity. Neurotox Res. 2009 15(3):232-45.
  19. Justinova Z, Mangieri RA, Bortolato M, Chefer SI et al. Fatty acid amide hydrolase inhibition heightens anandamide signaling without reinforcing effects in primates. Biol Psychiatry. 2008 Dec 1;64(11):930-7.
  20. Bortolato M, Chen K, Shih J. Monoamine oxidase inactivation: From pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1527-33.
  21. Scott AL, Bortolato M, Chen K, Shih JC. Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport. 2008 May 7;19(7):739-43.
  22. Bortolato M, Mangieri RA, Fu J, Kim JH, et al. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry. 2007 Nov 15;62(10):1103-10.
  23. Ballmaier M, Bortolato M, Rizzetti C, Zoli M, et al. Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis. Neuropsychopharmacology. 2007 Oct;32(10):2098-107.
  24. La Rana G, Russo R, Campolongo P, Bortolato M, et al. Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404. J Pharmacol Exp Ther. 2006, 317(1-3): 1365-1371.
  25. Bortolato M, Frau R, Orru M, Casti A, et al. Prenatal exposure to a cannabinoid agonist does not affect sensorimotor gating in rats. European Journal Pharmacology. 2006, 531 (1-3):166-70.
  26. Gobbi G, Bambico FR, Mangieri R, Bortolato M, et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proceedings National Academy Science 2005, 102: 18620-18625
  27. Tambaro S, Bortolato M. Interactions of cannabis and amphetamine-type stimulants. In: Cannabinoids, endocannabinoids, and modulation of emotion, memory and motivation.  eds. L. Fattore, P. Campolongo, Springer, in press
  28. Bortolato M, Piomelli D. The endocannabinoid system and anxiety responses. In Handbook of Fear and Anxiety, Volume 17, eds. R.J.Blanchard, D.C.Blanchard, G.Griebel, D.Nutt, Elsevier Science, 2008
  29. Stetler DA, Davis C, Leavitt K, Schriger I, Benson K, Bhakta S, Wang LC, Oben C, Watters M, Haghnegahdar T, Bortolato M. (2014). Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders. Journal of Psychiatric Research. 58:69-75.
  30. Godar SC, Bortolato M, Castelli MP, Casti A, Casu A, Chen K, Ennas MG, Tambaro S, Shih JC. (2014) The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. Journal of Psychiatric Research. 56:1-9.
  31. Godar SC, Bortolato M, Richards SE, Li FG, Chen K, Wellman CL, Shih JC. (2015) Monoamine oxidase A is required for rapid dendritic remodeling in response to stress. International Journal of Neuropsychopharmacology. (In Press)
Merlin G. Butler Selected Publications
  1. Butler, M.G. & Palmer, W.G.  (1983).  Parental origin of chromosome 15 deletion in Prader-Willi syndrome.  Lancet I:1285-1286.
  2. Butler, M.G., Pratesi, R., & Vnencak-Jones, C.L.  (1995).  Molecular genetic analysis of mentally retarded males with features of the fragile X syndrome.  J. Intell. Disabil. Res. 39:544-553.
  3. Ebert, M.H., Schmidt, D.E., Thompson, T., & Butler, M.G.  (1997).  Elevated plasma gamma-amino butyric acid (GABA) levels in individuals with Prader-Willi or Angelman syndromes.  J. Neuropsych. & Clin. Neurosci. 9:75-80.
  4. Schuback, D.E., Mulligan, E.L., Sims, K.B., Tivol, E.A., Greenberg, F.D., Chang, S.F., Yang, S.L., Mau, Y.C., Shen, C.Y., Ho, M.S., Yang, N.H., Butler, M.G., Fink, S., Schwartz, C.E., Berlin, F., Breakefield, X.O., Murphy, D.L., & Hsu, Y.P.  (1999).  Screen for MAOA mutations in target human groups.  Am. J. Med. Genet. 1:25-28.
  5. Ohta, T., Gray, T., Rogan, P.K., Buiting, K., Gabriel, J.M., Saitoh, S., Muralidhar, B., Driscoll, D.J., Horsthemke, B., Butler, M.G., & Nicholls, R.D.  (1999).  Imprinting mutation mechanisms in Prader-Willi syndrome represent a new paradigm for genetic disease.  Am. J. Hum. Genet. 64:397-413.
  6. Symons, F.J., Butler, M.G., Sanders, M.D., Feurer, I.D., & Thompson, T.  (1999).  Self-Injurious behavior and Prader-Willi syndrome: Behavioral forms and body locations.  Am. J. Ment. Retard. 104(3):260-269.
  7. Dimitropoulos, A., Feurer, I.D., Roof, E., Stone, W., Butler, M.G., Sutcliffe, J., & Thompson, T.  (2000).  Appetitive behavior, compulsivity and neurochemistry in Prader-Willi syndrome.  MRDD Res. Rev. 6:125-130.
  8. Talebizadeh, A., Bittel, D.C., Miles, J.H., Takahashi, N., Wang, C.H., Kibiryeva, N., & Butler, M.G. (2002). No association between HOXA1 and HOXB1 genes and autism spectrum disorders (ASD) J. Med. Genet. 39:e70(
  9. Butler, M.G., Bittel, D.C., Kibiryeva, N., Talebizadeh Z. & Thompson, T. (2004).  Behavioral  differences among subjects with Prader-Willi syndrome and type I and type II deletions and maternal disomy.  Pediatrics 113: 565-574.
  10. Hartley, S., MacLean, W., Butler, M.G., Zarcone, J., & Thompson, T. (2005).  Maladaptive behaviors and risk factors among the genetic subtypes of Prader-Willi syndrome.  Am. J. Med. Genet. 136A:140-145.
  11. Butler, M.G., Dasouki, M.J., Miles, J., Zhou, X. P., Brown, M., Talebizadeh, Z., Wang, C.H., Takahashi, T.N., Stratton, R., Pilarski, R., & Eng, C. (2005).  Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations.  J. Med. Genet. 42:318-321.
  12. Talebizadeh, Z., Bittel, D.C., Veatch, O., Kibiryeva, & Butler, M.G. (2005).  Skewed X chromosome inactivation in females with autism.  J. Autism Develop. Disord. 35:675-681.
  13. Holsen, L.M., Zarcone, J.R., Brooks, W.M., Butler, M.G., Thompson, T.I., Ahluwalia, J.S., Nollen, N.G., & Savage, C.R. (2006).  Neural mechanisms underlying hyperphagia in Prader-Willi syndrome.  Obesity 14:1028-1037.
  14. Talebizadeh, Z., Lam, D.Y., Theodoro, M.F., Bittel, D.C., Lushington, G.H., & Butler, M.G. (2006).  Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism.  J. Med. Genet. 43(5):e21 (
  15. Bittel, D.C., Kibiryeva, N., & Butler, M.G. (2006).  Expression of four genes between chromosome 15 breakpoints BP1 and BP2 and behavioral outcomes in Prader-Willi syndrome. Pediatrics 118:e1276-1283.
  16. Zarcone, J., Napolitano, D., Peterson, C., Breidbord, J., Ferraioli, S., Caruso-Anderson, M., Holsen, L., Butler, M.G., & Thompson, T. (2007).  The relationship of compulsive behavior to academic achievement in individuals with Prader-Willi syndrome.  J. Intellect. Disabil. Res. 51:478-487.
  17. Holsen, L.M., Zarcone, J.R., Chambers, R., Butler, M.G., Bittel, D., Brooks, W.M., Thompson, T.I., & Savage, C.R. (2009).  Genetic subtype differences in neural circuitry of food motivation in Prader-Willi syndrome. International. Int. J. Obes (Lond). 33:273-283.
  18. Bittel, D.C., Yu, S., Newkirk, H., Kibiryeva, N., Holt, A., Butler, M.G., & Cooley, L.D. (2009). Refining the 22q11.2 deletion breakpoints in DiGeorge syndrome by aCGH. Cytogenet. Genome Res.124:113-120.
  19. Henkhaus, R.S., Bittel, D.C. & Butler, M.G. (2010). TPH2 polymorphisms and expression in Prader-Willi syndrome subjects with differing genetic subtypes. J. Neurodev. Disord. 2:144-148.
  20. Martin, L.E., Holsen, L.M., Chambers, R.J., Bruce, A.S., Brooks, W.M., Zarcone, J.R., Butler, M.G., & Savage, C.R. (2010). Neural mechanisms associated with food motivation in obese and healthy weight adults. Obesity 18:254-260.
  21. Bruce, A.S., Holsen, L.M., Chambers, R.J., Martin, L.E.,  Brooks, W.M., Zarcone, J.R., Butler, M.G., & Savage, C.R. (2010). Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward, and cognitive control. Internat. J. Obes. (Lond). 34:1494-1500.
  22. Dykens, E., Roof, E., Bittel, D., & Butler, M.G. (2011). TPH2  G/T polymorphism is associated with hyperphagia in Prader-Willi syndrome. J. Child Psychol. Psychiatry. 52(5):580-587.
  23. Burnside, R.D., Pasion, R., Mikhail, F.M., Carroll, A.J., Robin, N.H., Youngs, E., Gadi, I.K., Keitges, E., Jaswaney, V.L., Papenhausen, P.R., Potluri, R., Risheg, H., Smith, J.L., Schwartz, S.,Tepperberg, J.H.. & Butler, M.G. (2011). Microdeletion/microduplication of proximal 15q11.2 between BP1 and BP2: A susceptibility region for neurological dysfunction including developmental and language delay. Hum. Genet. 130(4):517-528.
  24. Butler, M.G. (2011). Prader-Willi syndrome: Obesity due to genomic imprinting. Curr. Genomics 12(3):204-215.
  25. Holsen, L.M., Savage, C.R., Martin, J.E., Bruce, A.S., Lepping, R.C., Ko, E., Brooks, W.M., Butler, M.G., Zarcone, J.R., &  Goldstein, J.M. (2012). Importance of prefrontal inhibitory circuitry in hunger and satiation: The case of Prader-Willi syndrome vs. simple obesity. Int. J. Obesity 36:638-647.
  26. Honea, R.A., Holsen, L.M., Lepping, R.J., Perea, R., Butler, M.G., Brooks, W.M. & Savage, C.R. (2012). The neuroanatomy of genetic subtype differences in Prader-Willi syndrome. Am. J. Med. Genet. B. (Neuropsychiatr Genet).159B(2):243-253.
  27. Youngs, E.L., Henkhaus, R., Hellings, J.A. & Butler, M.G. (2012). IL1RAPL1 gene deletion as a cause of X-linked mental retardation. Eur. J. Med. Genet. 55:32-36.
  28. Butler, M.G., Youngs, E.L., Roberts, J.L. & Hellings, J.A. (2012). Assessment and treatment in autism spectrum disorders: A focus on genetics and psychiatry. Autism Res. Treat. 2012:242537.
  29. Mayo-Ortega, L., Oyama-Ganiko, R., Leblanc, J., Schroeder, S.R., Brady, N., Butler, M.G., Reese, R.M., Richman, D.M., Peacock, G., Foster, J. & Marquis, J. (2012). Mass screening for severe problem behavior among infants and toddlers in Peru. J. Ment. Health Res. Intellect. Disabil. 5(3-4):246-259.
  30. Mettman, D.J., Penick, E.C., Poje, A.B., Butler, M.G.,& Manzardo, A.M. (2013). Androgen receptor gene polymorphism is associated with impulsivity and alcoholism severity in women with alcoholism. Adv. Genomics Genet., in press
  31. Schroeder, S. R., Marquis, J., Reese, R.M., Richman, D.M., Mayo-Ortega, L., Oyama-Ganiko, R., LeBlanc, J., Brady, N., Butler, M.G., Peacock, G., Foster, J., Johnson, T. & Lawrence, L. (2013). Risk factors for self-injury, aggression, and stereotyped behavior among infants and toddlers at risk for intellectual and developmental disabilities. Am. J. Intell. Dev. Disabil., in press
  32. Roberts, J.L., Hovanes, K., Dasouki, M., Manzardo, A.M. & Butler, M.G. (2013). Chromosomal microarrayanalysis of individuals with autism spectrum disorders or learning disability presenting for genetic services. Gene. 535(1):70-78
Paula Fite Selected Publications

Peer Reviewed Publications

Fite, P. J., *Rubens, S., *Preddy, T. M., Raine, A., & Pardini, D. A. (in press). Reactive/Proactive Aggression and the Development of Internalizing Problems: The Moderating Effect of Parent and Peer Relationships. Aggressive Behavior.

Fite, P. J., *Hendrickson, M., *Rubens, S. L., *Gabrielli, J., & *Evans, S. (2013). The Role of Peer Rejection in the Link between Reactive Aggression and Academic Performance. Child and Youth Care Forum, 42, 193-205.

Fite, P. J., *Rathert, J. L., *Grassetti, S., *Gaertner, A. E., *Campion, S., & Fite, J. L., & *Vitulano, M. (2011). Longitudinal Investigation of the Link between Proactive and Reactive Aggression and Disciplinary Actions. Journal of Psychopathology and Behavioral Assessment, 33, 205-214.

Fite, P. J., Raine, A., Loeber, R., Stouthamer-Loeber, M., & Pardini, D. A. (2010). Reactive and Proactive Aggression in Adolescent Males: Examining Differential Outcomes 10 Years Later in Early Adulthood. Criminal Justice and Behavior 37(2), 141-157.

Fite, P. J., Stoppelbein, L., & Greening, L. (2009). Proactive and reactive aggression in a child psychiatric inpatient population. Journal of Clinical Child and Adolescent Psychology, 38, 199-205.

Fite, P. J., Colder, C. R., Lochman, J. E., & Wells, K. C. (2007). Pathways from proactive and reactive aggression to substance use. Psychology of Addictive Behaviors, 21, 355-364.

*Cooley, J. L., Fite, P. J., Rubens, S. L., & *Tunno, A. M. (in press). Peer Victimization, Depressive Symptoms, and Rule-Breaking Behavior in Adolescence: The Moderating Role of Peer Social Support. Journal of Psychopathology and Behavioral Assessment.

*Evans, S. C., Fite, P. J., *Hendrickson, M. L., *Rubens, S. L., & *Mages, A. (in press). The Role of Reactive Aggression in the Link between Hyperactive-Impulsive Behaviors and Peer Rejection in Adolescents. Child Psychiatry and Human Development.

Fite, P.J., *Brown, S. *Gabrielli, J., *DiPierro, M., *Pederson, C., *Blossom, J. B., *Cooley, J. L., & Bortolato, M. (in press). The role of negative life events in comorbid reactive aggression and marijuana use among Latino Adolescents. Journal of Aggression, Maltreatment and Trauma.

Fite, P. J., *Gabrielli, J., *Cooley, J. L., *Rubens, S. L., *Pederson, C. A., & Vernberg, E. M. (in press). Associations between Physical and Relational Forms of Peer Aggression and Victimization and Risk for Substance Use among Elementary School-Age Youth. Journal of Child and Adolescent Substance Abuse.

*Rathert, J., *Pederson, C. A., Fite, P. J., Stoppelbein, L., & Greening, L. (in press). Associations between Proactive and Reactive Aggression, Parenting Styles, and Externalizing Symptomatology in Children Admitted to a Psychiatric Inpatient Unit. Journal of Child and Family Studies.

Raiker, J. S., Greening, L., Stoppelbein, L., Becker, S. P., Fite, P. J., & Luebbe, A. M. (in press). Mediating Effect of Psychopathy on the Risk of Social Problems among Children with ADHD versus Sluggish Cognitive Tempo Symptoms. Child Psychiatry and Human Development.

Shorey, R. C., Fite, P. J., Choi, H., Cohen, J. R., Stuart, G. L., & Temple, J. R. (in press). Dating violence and substance use as longitudinal predictors of ethnically diverse adolescents' risky sexual behavior. Prevention Science.

*Shorey, R. C., *Sherman, A. E., *Brasfield, H., *Febres, J., Fite, P. J. & Stuart, G. L. (in press). The Moderating Effect of Perceived Support from a Dating Partner on the Association between Dating Violence Victimization and Adjustment. Violence Against Women.

Fite, P. J., Becker, S. P., Rubens, S. L., & *Cheetham-Johnson, R. (2015). Anxiety Symptoms Account for the Link between Reactive Aggression and Sleep Problems among Latino Adolescents. Child and Youth Care Forum, 44, 343-354.

Elkins, S., Fite, P. J., Moore, T., Lochman, J. E., & Wells, K. C. (2014). Bidirectional Effects of Parenting and Youth Substance Use during the Transition to Middle and High School. Psychology of Addictive Behaviors, 28, 475-486.

Fite, P. J., *Cooley, J. L., Williford, A., *Frazer, A., & *DiPierro, M. (2014). Parental School Involvement as a Moderator of the Association between Peer Victimization and Academic Performance. Children and Youth Services Review, 44, 25-32.

Fite, P.J., *Evans, S., *Cooley, J., & *Rubens, S. (2014). Further Evaluation of Associations between Attention-Deficit/Hyperactivity and Oppositional Defiance Symptoms and Bullying-Victimization in Adolescence. Journal of Child Psychiatry and Human Development, 45, 32-41.

Fite, P. J., *Gabrielli, J., *Cooley, J. L., Haas, S. M., Frazer, A., Rubens, S. L., & Johnson-Motoyama, M. (2014). Hope as a Moderator of the Associations between Common Risk Factors and Frequency of Substance Use. Journal of Psychopathology and Behavioral Assessment, 36, 653-662.

Fite, P. J., *Hendrickson, M., *Evans, S., *Rubens, S. L., Johnson-Motoyama, M., & *Savage, J. (2014). Associations between Proactive and Reactive Subtypes of Aggression and Lifetime Substance Use in a Sample of Predominantly Hispanic Adolescents. Journal of Child and Adolescent Substance Abuse, 23, 398-406.

Fite, P. J., Johnson-Motoyama, M., *Rubens, S. L., & Peaches, A. (2014). Risk for Being a Teen Parent: The influence of Proactive and Reactive Aggression in a sample of Latino Adolescents. Child Indicators Research, 7, 437-450.

Harris, A. N., Stoppelbein, L., Greening, L., Becker, S., Luebbe, A., Fite, P. J. (2014).  Child routines and parental adjustment as correlates of internalizing and externalizing children diagnosed with ADHD.  Child Psychiatry and Human Development, 45, 243-253. 

*Pederson, C., & Fite, P. J. (2014). The impact of Parenting on the Associations between Child Aggression Subtypes and Oppositional Defiant Disorder Symptoms. Child Psychiatry and Human Development, 45, 728-735.

*Preddy, T. M., Fite, P. J., *Wimsatt, A. R., *Vitulano, M. L., & *Gaertner, A. E. (2014). The Role of Intimate Exchange in the Link between Reactive Aggression and Child Depressive Symptoms. Journal of Child and Family Studies, 23, 510-520.

*Rubens, S. L., Fite, P. J., *Cooley, J. L., & *Canter, K. (2014). The Role of Sleep in the Relation between Community Violence Exposure and Delinquency among Latino Adolescents. Journal of Community Psychology, 42, 723-734.

Stoppelbein, L., Greening, L., Luebbe, A., Fite, P., & Becker, S (2014).  The role of cortisol and psychopathic traits in aggression among at-risk girls: Tests of mediating hypotheses.  Aggressive Behavior, 40, 263-272.

Williford, A., Fite, P. J., & *Cooley, J. L. (2014). Student-Teacher congruence in Reported Rates of Physical and Relational Victimization among Elementary School-Age Children” The Moderating Role of Gender and Age. Journal of School Violence, 13, 1-19.

*Vitulano, M. L., Fite, P. J., Hopko, D. R., Lochman, J. E., Wells, K., & Asif, I. (2014). Evaluation of Underlying Mechanisms in the Link between Childhood ADHD Symptoms and Risk for Early Initiation of Substance Use. Psychology of Addictive Behaviors, 28, 816-827.

*Denotes student authors

Erik A. Lundquist Selected Publications
  • Demarco, R.S., Struckhoff, E.C., and Lundquist, E.A.  The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance. 2012, 8:4, e1002665.
  • Huarcaya Najarro, E., Wong, L., Zhen, M., Pinedo Carpio, E., Goncharov, A., Garriga, G., Lundquist, E.A., Jin, Y., and Ackley, B.D. Caenorhabditis elegans Flamingo cadherin fmi-1 regulates GABAergic neuronal development. 2012 Mar 21;32(12):4196-211.
  • Alan, J.K., and Lundquist ,E.A.  Analysis of Rho GTPase Function in Axon Pathfinding Using Caenorhabditis elegans.  Methods Mol Bio 2012; 827:339-58.
  • Norris, A.D., and Lundquist, E.A. UNC-6/Netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.  Development 2011, 138:4433-4442.
  • Demarco, R.S. and Lundquist, E.A.  Extra Views:  “RACK”-ing up the effectors:  receptor for activated C kinase acts downstream of Rac GTPase signaling in growth cone outgrowth.  Small GTPases 2011, 2:1, 1-4.
  • Demarco, R.S. and Lundquist, E.A.  RACK-1 acts cell autonomously with Rac GTPase signaling and UNC-115/abLIM in C. elegans axon pathfinding and cell migration. PLOS Genetics 2010, 6:11 e1001215.
  • Dyer (Chapman), J.O., Demarco, R.S., Lundquist, E.A. Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans. Small GTPases 2010 1:1, pp. 44-61.
  • Norris, A.D., Dyer (Chapman), J.O., and Lundquist, E.A. The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in C. elegans. Neural Development 2009, 2;4:38.
  • Lundquist EA.  Primer:  The Finer Points of Filopodia. PLoS Biol. 2009 Jun 30;7(6):e1000142. Epub 2009 Jun 30.
  • Hueston JL, Purinton Herren G, Cueva JG, Buechner M, Lundquist EA, Goodman MB, Suprenant KA. The C. elegans EMAP-like protein, ELP-1 is required for normal touch sensation and associates with microtubules and adhesion complexes. BMC Dev Biol. Nov 17;8(1):110, 2008.
  • J.O. Chapman, H. Li, and E.A. Lundquist. “The MIG-15 NIK kinase acts cell-autonomously in neuroblast polarization and migration in C. elegans.Developmental Biology, Dec 15;324(2):245-57, 2008.
  • M.A. Shakir, K. Jiang, E.C. Struckhoff, R.S. Demarco, F.B. Patel, M.C. Soto, and E.A. Lundquist.    “The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in C. elegans axon guidance.”  Genetics 179(4):1957-1971, 2008. PMCID: PMC2516072.
  • J. Lu, W.L. Dentler, and E.A. Lundquist. “FLI-1 Flightless-1 acts with LET-60 Ras to control germ line morphogenesis in C. elegans.” BMC Dev Biol. May 16;8:54, 2008.
  • Y. Yang, J. Lu, S. Quackenbush, J. Rovnak, and E.A. Lundquist. “SWAN-1, a C. elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function.”  Genetics 174(4):1917-32, 2006.
  • M.A. Shakir, J. Gill, and E.A. Lundquist.  “Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Axon Pathfinding and Neuronal Migration in C. elegans.” Genetics 172(2); 893-913, 2006.
  • Y. Yang and E.A. Lundquist. “The actin-binding protein UNC-115/abLIM controls lamellipodia and filopodia formation and neuronal morphogenesis in C. elegans.”  Mol Cell Biol 25, 5158-5170, 2005.
  • E.A. Lundquist.  “Signal transduction:  Small GTPases.”  Wormbook, Jan 17: 1-18, 2006.
  • M.A. Shakir and E.A. Lundquist.  “Analysis of Cell Migration in Caenorhabditis elegans.”  Methods Mol Biol. 294: 159-74, 2004.
  • J.L. Yanowitz, M.A. Shakir, E. Hedgecock, H. Hutter, A.Z. Fire, and E.A. Lundquist.  “UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation.”  Developmental Biology 272: 389-402, 2004.
Ann Manzardo Selected Publications
  1. Manzardo AM, Penick EC, Knop J, Nickels EJ, Hall S, Jensen P, Gabrielli WF (2005) Developmental differences in childhood motor coordination predict adult alcohol dependence: Proposed role for the cerebellum in alcoholism. Alcoholism: Clinical and Experimental Research 29(3):353-357, PMID: 15770110
  2. Manzardo AM, Penick EC, Knop J, Nickels EJ, Hall S, Miller C, Jensen P, Gabrielli WF (2005) Neonatal vitamin K might reduce vulnerability to alcohol dependence in Danish men. Journal on Studies of Alcohol 66:586-592, PMID: 16331844.
  3. Manzardo AM, Penick EC (2006) A theoretical argument for inherited thiamine insensitivity as one possible biological cause of familial alcoholism. Alcoholism: Clinical and Experimental Research 30(9):1545-1550, PMID: 16930217.
  4. O'Dell LE, Manzardo AM, Polis I, Stouffer DG, Parsons LH (2006) Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration. Journal of Neurochemistry 99(5): 1363-1376, PMID: 17074068.
  5. Knop J, Penick EC, Nickels EJ, Mednick SA, Jensen P, Manzardo AM, Gabrielli WF (2007) Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: a forty-year follow-up. Acta Psychiatrica Scandinavia 116(5): 386-393, PMID: 17919158.
  6. Knop J, Penick EC, Nickels EJ, Mortensen EL, Mednick SA, Jensen P, Manzardo AM, Gabrielli WF (2009) Childhood ADHD and conduct disorder as independent predictors of male alcohol dependence at age 40. Journal of Studies on Alcohol and Drugs Mar; 70(2):169-77, PMCID: PMC2653603
  7. Penick EC, Knop J, Nickels EJ, Jensen P, Manzardo AM, Mortensen EL, Gabrielli WF (2010) Do premorbid predictors of alcohol dependence also predict the failure to recover from alcoholism? Journal of Studies on Alcohol and Drugs Sep; 71(5):685-95, PMCID: PMC2930498.
  8. Manzardo AM, Madarasz W, Penick EC, Knop J, Mortensen EL, Sorensen HJ, Mahnken J, Becker U, Nickels EJ, Gabrielli WF (2011) Effects of premature birth on the risk for alcoholism appear to be greater in males than females. Journal of Studies on Alcohol and Drugs May; 72(3):390-98, PMCID: PMC3084356.
  9. Sorensen HJ,  Manzardo AM, Knop J, Penick EC, Madarasz W, Nickels EJ, Gabrielli WF, Becker U, Mortensen EL (2011) The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring.  Alcoholism Clinical and Experimental Research Jul; 35(7):1315-1320, PMCID: PMC3653408.
  10. Manzardo AM, Henkhaus R, Butler MG (2012) Genome-wide promoter methylation in frontal cortex of alcoholics and controls. Gene Apr, 498(1): 5-12, PMCID: PMC3653411.
  11. Manzardo AM, Henkhaus R, Hidakka B, Penick EC, Poje A, Butler MG (2012) X Chromosome Inactivation in Blood from Women with Alcoholism. Alcoholism Clinical and Experimental Research Aug, 36(8): 1325-9, PMCID: PMC3371305.
  12. Madarasz W, Manzardo AM, Mortensen EL,  Penick EC,  Knop J, Sorensen HJ, Becker U, Nickels EJ, Gabrielli WF (2012) 45-year mortality rate as a function of the number and type of psychiatric diagnosis found in a large Danish birth cohort, Canadian Journal of Psychiatry, Aug, 57(8):505-511, PMID: 22854033
  13. Manzardo AM, Gunewardena S, Butler MG (2013) Over-expression of miRNA cluster at 14q32 in the alcoholic brain correlates with suppression of mRNA activated in oligodendrocyte proliferation, Gene, 526 (2): 356-63, PMID: 23747354.
  14. Manzardo AM, Poje A, He J, Penick EC, Butler MG, Campbell J (2013) Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence, Drug and Alcohol Dependence, 133(2): 562-570.
  15. Mettman DJ, Butler MG, Poje AB, Penick EC, Manzardo AM: Androgen receptor gene polymorphism: an association with impulsivity in women with alcoholism. Advances in Genomics and Genetics, in press
  16. Manzardo AM, Gunewardena S, Wang K, Butler MG, Exon Microarray Analysis of Human Dorsolateral Prefrontal Cortex in Alcoholism, Alcoholism Clinical and Experimental Research, in review, 2014.


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